human hcc cell lines thle-3 Search Results


normal hepatocyte cell line thle 3  (ATCC)
96
ATCC normal hepatocyte cell line thle 3
Normal Hepatocyte Cell Line Thle 3, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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bronchial epithelial growth medium (begm)  (Lonza)
90
Lonza bronchial epithelial growth medium (begm)
Bronchial Epithelial Growth Medium (Begm), supplied by Lonza, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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human hepatocytes  (ATCC)
98
ATCC human hepatocytes
Figure 1. Human <t>hepatocytes</t> express PD-L1 but not PD-1 and CTLA-4. (A) The levels of PD-L1 expression were evaluated by Western blotting in whole cell lysates (WCLs) of human primary hepatocytes (HPH) and human hepatocytes (THLE-2 cells). (B) The levels of PD-L1 were evaluated by Western blotting in WCLs of THLE-2, JIMT1, and MDA-MB-231 cells. (C) The levels of PD-L1, PD-1, and CTLA-4 expression were evaluated by Western blotting in WCLs of activated T cells and THLE-2 cells after 24 h after treatment of 100 µg/mL ipilimumab (IPIL), nivolumab (NIV), and left untreated. Western blotting panels shown in this figure are representative of at least two or three independent experiments.
Human Hepatocytes, supplied by ATCC, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+hcc+cell+lines+thle-3/pm37511454-272-0-8?v=ATCC
Average 98 stars, based on 1 article reviews
human hepatocytes - by Bioz Stars, 2026-08
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human hepatocyte line  (ATCC)
95
ATCC human hepatocyte line
Figure 1. Human <t>hepatocytes</t> express PD-L1 but not PD-1 and CTLA-4. (A) The levels of PD-L1 expression were evaluated by Western blotting in whole cell lysates (WCLs) of human primary hepatocytes (HPH) and human hepatocytes (THLE-2 cells). (B) The levels of PD-L1 were evaluated by Western blotting in WCLs of THLE-2, JIMT1, and MDA-MB-231 cells. (C) The levels of PD-L1, PD-1, and CTLA-4 expression were evaluated by Western blotting in WCLs of activated T cells and THLE-2 cells after 24 h after treatment of 100 µg/mL ipilimumab (IPIL), nivolumab (NIV), and left untreated. Western blotting panels shown in this figure are representative of at least two or three independent experiments.
Human Hepatocyte Line, supplied by ATCC, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+hcc+cell+lines+thle-3/pmc05636223-166-1-5?v=ATCC
Average 95 stars, based on 1 article reviews
human hepatocyte line - by Bioz Stars, 2026-08
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thle 3  (ATCC)
94
ATCC thle 3
Figure 1. Human <t>hepatocytes</t> express PD-L1 but not PD-1 and CTLA-4. (A) The levels of PD-L1 expression were evaluated by Western blotting in whole cell lysates (WCLs) of human primary hepatocytes (HPH) and human hepatocytes (THLE-2 cells). (B) The levels of PD-L1 were evaluated by Western blotting in WCLs of THLE-2, JIMT1, and MDA-MB-231 cells. (C) The levels of PD-L1, PD-1, and CTLA-4 expression were evaluated by Western blotting in WCLs of activated T cells and THLE-2 cells after 24 h after treatment of 100 µg/mL ipilimumab (IPIL), nivolumab (NIV), and left untreated. Western blotting panels shown in this figure are representative of at least two or three independent experiments.
Thle 3, supplied by ATCC, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+hcc+cell+lines+thle-3/pmc10807943-111-49-50?v=ATCC
Average 94 stars, based on 1 article reviews
thle 3 - by Bioz Stars, 2026-08
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human liver epithelial cell line thle  (ATCC)
86
ATCC human liver epithelial cell line thle
Figure 1. Human <t>hepatocytes</t> express PD-L1 but not PD-1 and CTLA-4. (A) The levels of PD-L1 expression were evaluated by Western blotting in whole cell lysates (WCLs) of human primary hepatocytes (HPH) and human hepatocytes (THLE-2 cells). (B) The levels of PD-L1 were evaluated by Western blotting in WCLs of THLE-2, JIMT1, and MDA-MB-231 cells. (C) The levels of PD-L1, PD-1, and CTLA-4 expression were evaluated by Western blotting in WCLs of activated T cells and THLE-2 cells after 24 h after treatment of 100 µg/mL ipilimumab (IPIL), nivolumab (NIV), and left untreated. Western blotting panels shown in this figure are representative of at least two or three independent experiments.
Human Liver Epithelial Cell Line Thle, supplied by ATCC, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+hcc+cell+lines+thle-3/pmc04200221-205-0-9?v=ATCC
Average 86 stars, based on 1 article reviews
human liver epithelial cell line thle - by Bioz Stars, 2026-08
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human hepatic cell line thle3  (China Center for Type Culture Collection)
90
China Center for Type Culture Collection human hepatic cell line thle3
Figure 1. Human <t>hepatocytes</t> express PD-L1 but not PD-1 and CTLA-4. (A) The levels of PD-L1 expression were evaluated by Western blotting in whole cell lysates (WCLs) of human primary hepatocytes (HPH) and human hepatocytes (THLE-2 cells). (B) The levels of PD-L1 were evaluated by Western blotting in WCLs of THLE-2, JIMT1, and MDA-MB-231 cells. (C) The levels of PD-L1, PD-1, and CTLA-4 expression were evaluated by Western blotting in WCLs of activated T cells and THLE-2 cells after 24 h after treatment of 100 µg/mL ipilimumab (IPIL), nivolumab (NIV), and left untreated. Western blotting panels shown in this figure are representative of at least two or three independent experiments.
Human Hepatic Cell Line Thle3, supplied by China Center for Type Culture Collection, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+hcc+cell+lines+thle-3/pm28184924-23-2-10?v=China+Center+for+Type+Culture+Collection
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human hcc cell lines thle-3  (BioResource International Inc)
90
BioResource International Inc human hcc cell lines thle-3
Figure 1. Human <t>hepatocytes</t> express PD-L1 but not PD-1 and CTLA-4. (A) The levels of PD-L1 expression were evaluated by Western blotting in whole cell lysates (WCLs) of human primary hepatocytes (HPH) and human hepatocytes (THLE-2 cells). (B) The levels of PD-L1 were evaluated by Western blotting in WCLs of THLE-2, JIMT1, and MDA-MB-231 cells. (C) The levels of PD-L1, PD-1, and CTLA-4 expression were evaluated by Western blotting in WCLs of activated T cells and THLE-2 cells after 24 h after treatment of 100 µg/mL ipilimumab (IPIL), nivolumab (NIV), and left untreated. Western blotting panels shown in this figure are representative of at least two or three independent experiments.
Human Hcc Cell Lines Thle 3, supplied by BioResource International Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+hcc+cell+lines+thle-3/pmc04910248-48-1-14?v=BioResource+International+Inc
Average 90 stars, based on 1 article reviews
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hepatocytes thle 3  (ATCC)
97
ATCC hepatocytes thle 3
Figure 1. Human <t>hepatocytes</t> express PD-L1 but not PD-1 and CTLA-4. (A) The levels of PD-L1 expression were evaluated by Western blotting in whole cell lysates (WCLs) of human primary hepatocytes (HPH) and human hepatocytes (THLE-2 cells). (B) The levels of PD-L1 were evaluated by Western blotting in WCLs of THLE-2, JIMT1, and MDA-MB-231 cells. (C) The levels of PD-L1, PD-1, and CTLA-4 expression were evaluated by Western blotting in WCLs of activated T cells and THLE-2 cells after 24 h after treatment of 100 µg/mL ipilimumab (IPIL), nivolumab (NIV), and left untreated. Western blotting panels shown in this figure are representative of at least two or three independent experiments.
Hepatocytes Thle 3, supplied by ATCC, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+hcc+cell+lines+thle-3/us11614451-435-2-7?v=ATCC
Average 97 stars, based on 1 article reviews
hepatocytes thle 3 - by Bioz Stars, 2026-08
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thle 3 cell line  (ATCC)
97
ATCC thle 3 cell line
Figure 1. Human <t>hepatocytes</t> express PD-L1 but not PD-1 and CTLA-4. (A) The levels of PD-L1 expression were evaluated by Western blotting in whole cell lysates (WCLs) of human primary hepatocytes (HPH) and human hepatocytes (THLE-2 cells). (B) The levels of PD-L1 were evaluated by Western blotting in WCLs of THLE-2, JIMT1, and MDA-MB-231 cells. (C) The levels of PD-L1, PD-1, and CTLA-4 expression were evaluated by Western blotting in WCLs of activated T cells and THLE-2 cells after 24 h after treatment of 100 µg/mL ipilimumab (IPIL), nivolumab (NIV), and left untreated. Western blotting panels shown in this figure are representative of at least two or three independent experiments.
Thle 3 Cell Line, supplied by ATCC, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+hcc+cell+lines+thle-3/pm26514924-69-11-51?v=ATCC
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thle 3 cell line - by Bioz Stars, 2026-08
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human normal fetal hepatic cell line  (ATCC)
94
ATCC human normal fetal hepatic cell line
Figure 1. Human <t>hepatocytes</t> express PD-L1 but not PD-1 and CTLA-4. (A) The levels of PD-L1 expression were evaluated by Western blotting in whole cell lysates (WCLs) of human primary hepatocytes (HPH) and human hepatocytes (THLE-2 cells). (B) The levels of PD-L1 were evaluated by Western blotting in WCLs of THLE-2, JIMT1, and MDA-MB-231 cells. (C) The levels of PD-L1, PD-1, and CTLA-4 expression were evaluated by Western blotting in WCLs of activated T cells and THLE-2 cells after 24 h after treatment of 100 µg/mL ipilimumab (IPIL), nivolumab (NIV), and left untreated. Western blotting panels shown in this figure are representative of at least two or three independent experiments.
Human Normal Fetal Hepatic Cell Line, supplied by ATCC, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+hcc+cell+lines+thle-3/pm34914965-51-0-22?v=ATCC
Average 94 stars, based on 1 article reviews
human normal fetal hepatic cell line - by Bioz Stars, 2026-08
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thle-3  (AcceGen Biotechnology)
N/A
THLE-3 cell line was derived from primary normal liver cells by infection with SV40 large T antigen. The cells express cytokeratin 18 and albumin in early passage, whereas higher-passage cells in logarithmic-phase growth also express
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Image Search Results


Figure 1. Human hepatocytes express PD-L1 but not PD-1 and CTLA-4. (A) The levels of PD-L1 expression were evaluated by Western blotting in whole cell lysates (WCLs) of human primary hepatocytes (HPH) and human hepatocytes (THLE-2 cells). (B) The levels of PD-L1 were evaluated by Western blotting in WCLs of THLE-2, JIMT1, and MDA-MB-231 cells. (C) The levels of PD-L1, PD-1, and CTLA-4 expression were evaluated by Western blotting in WCLs of activated T cells and THLE-2 cells after 24 h after treatment of 100 µg/mL ipilimumab (IPIL), nivolumab (NIV), and left untreated. Western blotting panels shown in this figure are representative of at least two or three independent experiments.

Journal: International journal of molecular sciences

Article Title: Atezolizumab Induces Necroptosis and Contributes to Hepatotoxicity of Human Hepatocytes.

doi: 10.3390/ijms241411694

Figure Lengend Snippet: Figure 1. Human hepatocytes express PD-L1 but not PD-1 and CTLA-4. (A) The levels of PD-L1 expression were evaluated by Western blotting in whole cell lysates (WCLs) of human primary hepatocytes (HPH) and human hepatocytes (THLE-2 cells). (B) The levels of PD-L1 were evaluated by Western blotting in WCLs of THLE-2, JIMT1, and MDA-MB-231 cells. (C) The levels of PD-L1, PD-1, and CTLA-4 expression were evaluated by Western blotting in WCLs of activated T cells and THLE-2 cells after 24 h after treatment of 100 µg/mL ipilimumab (IPIL), nivolumab (NIV), and left untreated. Western blotting panels shown in this figure are representative of at least two or three independent experiments.

Article Snippet: Human hepatocytes (THLE-2 and THLE-3) were purchased from ATCC (cat# CRL-2706 and cat# CRL-11233, Manassas, VA, USA, respectively) and were cultured in BEGM SingleQuots medium (Lonza, cat# CC3170, Basel, Switzerland) containing 10% FBS.

Techniques: Expressing, Western Blot

Figure 2. Atezolizumab alone causes cytotoxicity in human hepatocytes. (A) The levels of LDH released in the cell culture medium of human primary hepatocytes (HPH) were measured after the cells were treated with indicated concentration of ATE for 24 h. (B) The levels of LDH released in the cell culture medium of THLE-2 were measured after the cells were treated with indicated concentrations of ATE for 5, 24, and 48 h. (C) Cell viability was examined using MTT assay in THLE-2 cells after the cells were treated with indicated concentrations of ATE for 48 h. (D) Cell growth was examined in THLE-2 cells after the cells were treated with indicated concentrations of ATE for 48 h. (E) Cell growth was examined in THLE-3 cells after the cells were treated with indicated concentrations of ATE for 48 h. Hepatocyte cytotoxicity assays shown in this figure are representative of at least two or three independent experiments. * p-value < 0.05, ** p-value < 0.01, *** p-value < 0.001, **** p-value < 0.0001, and ns indicates no significant change.

Journal: International journal of molecular sciences

Article Title: Atezolizumab Induces Necroptosis and Contributes to Hepatotoxicity of Human Hepatocytes.

doi: 10.3390/ijms241411694

Figure Lengend Snippet: Figure 2. Atezolizumab alone causes cytotoxicity in human hepatocytes. (A) The levels of LDH released in the cell culture medium of human primary hepatocytes (HPH) were measured after the cells were treated with indicated concentration of ATE for 24 h. (B) The levels of LDH released in the cell culture medium of THLE-2 were measured after the cells were treated with indicated concentrations of ATE for 5, 24, and 48 h. (C) Cell viability was examined using MTT assay in THLE-2 cells after the cells were treated with indicated concentrations of ATE for 48 h. (D) Cell growth was examined in THLE-2 cells after the cells were treated with indicated concentrations of ATE for 48 h. (E) Cell growth was examined in THLE-3 cells after the cells were treated with indicated concentrations of ATE for 48 h. Hepatocyte cytotoxicity assays shown in this figure are representative of at least two or three independent experiments. * p-value < 0.05, ** p-value < 0.01, *** p-value < 0.001, **** p-value < 0.0001, and ns indicates no significant change.

Article Snippet: Human hepatocytes (THLE-2 and THLE-3) were purchased from ATCC (cat# CRL-2706 and cat# CRL-11233, Manassas, VA, USA, respectively) and were cultured in BEGM SingleQuots medium (Lonza, cat# CC3170, Basel, Switzerland) containing 10% FBS.

Techniques: Cell Culture, Concentration Assay, MTT Assay

Figure 3. Phosphorylated RIP3 and MLKL are increased in atezolizumab-treated human hepatocytes (THLE-2 cells) in a dose-dependent manner. (A) The levels of phosphorylated RIP3, RIP3, phospho- rylated MLKL, and MLKL expression were evaluated by Western blotting in WCLs of THLE-2 cells after the cells were treated with either indicated concentrations of ATE or left untreated as a control.

Journal: International journal of molecular sciences

Article Title: Atezolizumab Induces Necroptosis and Contributes to Hepatotoxicity of Human Hepatocytes.

doi: 10.3390/ijms241411694

Figure Lengend Snippet: Figure 3. Phosphorylated RIP3 and MLKL are increased in atezolizumab-treated human hepatocytes (THLE-2 cells) in a dose-dependent manner. (A) The levels of phosphorylated RIP3, RIP3, phospho- rylated MLKL, and MLKL expression were evaluated by Western blotting in WCLs of THLE-2 cells after the cells were treated with either indicated concentrations of ATE or left untreated as a control.

Article Snippet: Human hepatocytes (THLE-2 and THLE-3) were purchased from ATCC (cat# CRL-2706 and cat# CRL-11233, Manassas, VA, USA, respectively) and were cultured in BEGM SingleQuots medium (Lonza, cat# CC3170, Basel, Switzerland) containing 10% FBS.

Techniques: Expressing, Western Blot, Control

Figure 4. T-cell-derived conditioned medium (T−CM) enhances expression level of PD−L1 but not CTLA−4 in human hepatocytes (THLE−2 cells). (A) The levels of PD−L1, phosphorylated Akt (T308 and S473), total Akt, phosphorylated STAT1 (Y701 and Y727), and total STAT1 expression were evaluated

Journal: International journal of molecular sciences

Article Title: Atezolizumab Induces Necroptosis and Contributes to Hepatotoxicity of Human Hepatocytes.

doi: 10.3390/ijms241411694

Figure Lengend Snippet: Figure 4. T-cell-derived conditioned medium (T−CM) enhances expression level of PD−L1 but not CTLA−4 in human hepatocytes (THLE−2 cells). (A) The levels of PD−L1, phosphorylated Akt (T308 and S473), total Akt, phosphorylated STAT1 (Y701 and Y727), and total STAT1 expression were evaluated

Article Snippet: Human hepatocytes (THLE-2 and THLE-3) were purchased from ATCC (cat# CRL-2706 and cat# CRL-11233, Manassas, VA, USA, respectively) and were cultured in BEGM SingleQuots medium (Lonza, cat# CC3170, Basel, Switzerland) containing 10% FBS.

Techniques: Derivative Assay, Expressing

Figure 5. Both atezolizumab and T-CM induce necrosome formation in human hepatocytes (THLE-2 cells), and in turn, the induced necrosome causes hepatotoxicity in THLE-2 cells. (A) The levels of phosphorylated RIP3, RIP3, and PD-L1 expression were evaluated by Western blotting in WCLs of

Journal: International journal of molecular sciences

Article Title: Atezolizumab Induces Necroptosis and Contributes to Hepatotoxicity of Human Hepatocytes.

doi: 10.3390/ijms241411694

Figure Lengend Snippet: Figure 5. Both atezolizumab and T-CM induce necrosome formation in human hepatocytes (THLE-2 cells), and in turn, the induced necrosome causes hepatotoxicity in THLE-2 cells. (A) The levels of phosphorylated RIP3, RIP3, and PD-L1 expression were evaluated by Western blotting in WCLs of

Article Snippet: Human hepatocytes (THLE-2 and THLE-3) were purchased from ATCC (cat# CRL-2706 and cat# CRL-11233, Manassas, VA, USA, respectively) and were cultured in BEGM SingleQuots medium (Lonza, cat# CC3170, Basel, Switzerland) containing 10% FBS.

Techniques: Expressing, Western Blot